2 edition of Chemotheraphy of new pentavalent organic compounds of arsenic found in the catalog.
Chemotheraphy of new pentavalent organic compounds of arsenic
George W. Raiziss
|Statement||George W. Raiziss, M. Severac and John C. Moetsch.|
|Contributions||Severac, M., Moetsch, John C.|
|The Physical Object|
|Number of Pages||11|
Inorganic arsenic compounds are used in metal alloy manufacturing, electronics manufacturing (semiconductors), and as wood preservatives. They are also formed as by-products during the smelting of metals and coal combustion (ATSDR, ). Organic arsenic compounds are formed when arsenic combines with carbon. Organic arsenic compounds may be. Define pentavalent organic arsenicals. pentavalent organic arsenicals synonyms, pentavalent organic arsenicals pronunciation, pentavalent organic arsenicals translation, English dictionary definition of pentavalent organic arsenicals. adj. 1.
Atoms of arsenic can combine with atoms of other elements to form a variety of compounds. These can be divided into two categories, “inorganic” and “organic.” In this case, the term “organic” is used in its proper chemical sense, referring to molecules that have a framework of carbon atoms. In an “organic” arsenic compound, the arsenic atom is attached to a carbon that may, for. Dimethylarsinic acid (DMAs V) is the major urinary metabolite of inorganic relatively atoxic DMAs V is reduced in the body to the much more toxic and thiol-reactive dimethylarsinous acid (DMAs III).Glutathione S-transferase omega 1 (GSTO1) can catalyze this toxification step; however, its role in the reduction of DMAs V in vivo or by tissue extracts is by: 4.
Organic arsenic compounds found in fish and shellfish may account for significant dietary intake of arsenic. These compounds are much less toxic than inorganic arsenic. 1 Organic forms of arsenic have not been associated with cancer. Although arsenic is infamous as a poison, the many arsenic compounds have a wide variety of uses. Chemistry of Arsenic TABLE Important Classes of Organic Arsenic Compounds RAsX2 ~ R2ASX J RBAs [R~As]+X R5As (RAsY)n R2AS-X-ASR2 R3AsY l~AsX2 RAsO(OH)2 R2AsO(OH) 11 X = H. halogen, NR2, OR, SR, SeR, alkali metal, pseudohalogen Tr~organylarsine Tetraorganylarsonium salt (X = uninegative anion) Pentaorganyl arsenic Y = 0, S. NH, NR X = 0, S.
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RAIzIss, G. W., SEVERAC, M., AND MOETSCH, J. C.: Chemotherapy of new pentavalent organic compounds of arsenic, Transactions of section of pharmacology and Cited by: 9.
The minimum dose which killed at least 50 per cent. of the treated mice within twenty-four hours in the case of the inorganic, trivalent organic, and arsenobenzol compounds, and within three to four days in the ease of the pentavalent organic compounds organic compounds Subject Category: Chemicals and Chemical Groups see more details."Cited by: Arsenic covalently bonds with most nonmetals and metals, and forms stable organic compounds in both its trivalent and pentavalent states.
The most important compounds are white As (As 2 O 3), the sulfide, Paris green (copper acetoarsenite) [3Cu(AsO 2) 2 Cu(CH 3 COO) 2 ], calcium arsenate, and lead arsenate, the last three being used as. ing arsenic-containing ores (realgar) and salvaging and purifying the smoke. The organic arsenicals consist of an arsenic atom in its trivalent or pentavalent state linked covalently to a carbon atom.
Compared with the inorganic forms, the organic compounds are often more stable, less toxic, and excreted more rapidly. The past, present. major groups: inorganic arsenic compounds; organic arsenic compounds; and arsine gas. The most common trivalent inorganic arsenic compounds are arsenic trioxide, sodium arsenite and arsenic trichloride.
Pentavalent inorganic compounds include arsenic pentoxide, arsenic acid and arsenates, e.g. lead arsenate and calcium arsenate. the relationship between exposure to arsenic compounds via occupa-tion, ingestion, or medical use and skin cancer. Inreevaluation of the data determined that exposure to arsenic and arsenic-containing compounds was a cause of lung cancer in humans.
Finally, insupport for arsenic as a cause of human cancers was judged asCited by: A series of 12 organic arsonic acid compounds has been synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell by: Arsenic and arsenic compounds. (Environmental health criteria ; ) c − toxicity cals − toxicity nmental exposure ational Programme on Chemical Safety II.
WHO Task Group on Environmental Health Criteria for Arsenic and Arsenic Compounds ISBN 92 4 8 (NLM Classification: QV ). Of the inorganic arsenic compounds, arsenic trioxide, sodium arsenite and arsenic trichloride are the most common trivalent compounds, and arsenic pentoxide, arsenic acid and arsenates (e.g.
lead arsenate and calcium arsenate) are the most common pentavalent compounds. Common organic arsenic compounds include arsanilic acid, methylarsonic acid, dimethylarsinic acid (cacodylic acid), and arsenobetaine.
Arsenic is also incorporated into arsenolipids, arsenosugars, and other types of organic compounds. Inorganic and Organic Arsenic Compounds in the Environment Arsenic is the 20th most abundant element on Earth and is often present together with sulfide minerals (Rezanka and Sigler ).
Arch. Dermat. and Syph. ; 12 (RAIzIss, G. W., SEVERAC, M., AND MOETSCH, J. C.: Chemotherapy of new pentavalent organic compounds of arsenic, Transactions of Cited by: 9. Recently it was demonstrated that pentavalent arsenic can bind to biomolecules like phytochelatin  or form an unusual six-coordinate pentavalent arsenic complex with insect chitin by 'vicinal.
corresponding pentavalent compounds. The oral LD 50 values for inorganic arsenic compounds, depending on the arsenic species and the experimental animal, are in the range from 7 to mg/kg body weight (Marquardt ). The clinical symptoms after the ingestion of arsenic compounds occur within 30 to 60 Size: 94KB.
out electroporation the pentavalent arsenic compounds and arsenite were able to induce genotoxic effects. Fig. 1: Cyt otoxicity of ars enic compounds after an incubation time of 1h. ; Ko, ). Pentavalent arsenic is used to treat advanced trypanosomiasis and acute promyelocytic leukemia (APL) is treated with arsenic trioxide (Novick and Warrell, ; Soignet et al., ).
In seafood, arsenic present in its organic form with elevated concentration, which are considerably less toxic than inorganic arsenic (ATSDR, ).File Size: KB. Overall, organic arsenicals in the pentavalent oxidation state are much less toxic than inorganic arsenicals because, unlike inorganic arsenic, these ingested organic arsenicals are not readily taken up into cells and undergo limited metabolism (Cohen et al., ).Cited by: In the first paper of this series the authors, with ADAMS, showed that the action of drugs on trypanosomes.
could be studied in vitro provided that serum of rabbit, ox, sheep, horse or pig was used as supporting medium, whereby the trypanosomes are kept alive for at least 24 hours at 37° C. ; the concentration of the parasites must not exceed a certain level [this Bulletin, Vol.
27, p. ].Cited by: state (trivalent are more toxic than pentavalent compounds), the physical state of the compound, and the rates of absorption and elimination.
Elemental arsenic (the metalloid) is non-toxic even if eaten in substantial amount Inorganic forms of arsenic are more toxic than organic forms. Arsenic has been shown to produce. Arsenic is a potentially toxic element to humans, animals and plants.
Exposure of humans to arsenic and its compounds may originate from both natural and anthropogenic sources, including industrial activities, and consumption of food and beverages. Arsenic is found in nature in a variety of inorganic and organic : Milena Horvat, Zdenka Šlejkovec, Ingrid Falnoga.
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Determination of inorganic arsenic and methylarsenic compounds by gas chromatography and multiple ion detection mass spectrometry after hydride generation-heptane cold trap technique.
Analytical Chemistry55 (6), DOI: /aca Robert H. Christenson and C. by: The oxidation state of arsenic in arsenic trioxide is +3 (trivalent). Trivalent arsenic is known to be more toxic than the pentavalent arsenic (oxidation state = +5).
The reason for the differential toxicity is that a trivalent arsenic binds to thiol group found in a wide variety of proteins far more readily than a pentavalent arsenic.standards limit arsenic to no more than mg/L. When present in drinking water, arsenic can be either in the pentavalent form (also known as arsenic 5 or arsenate) or the trivalent form (also known as arsenic 3 or arsenite).
Although both arsenic types are potentially harmful to human health,File Size: KB.